Son of John W. Wilkerson and Rebecca H. Kilgore. He had 4 children from his first marriage: Julia Ann Wilkerson, John W. Wilkerson Jr., Thomas H. Wilkerson and Rebecca A. Wilkerson. He remarried to Melinda Hathcock on 12th March 1883. They had 6 children: Samuel Matthew Wilkerson, John Isaiah Wilkerson, Malinda D. Wilkerson, Jackson Wilkerson, Frances Teria Wilkerson and Luther M. Willkerson.
23671900 Census of Oneonta, Blount Co AL
Household Members	Age	RelationshipJohn W Wilkerson        	39	Head
Malinda Wilkerson      	42	Wife
Rebecca Wilkerson      	16	Daughter
Samuel M Wilkerson	15	Son
James I Wilkerson       	13	Son
Malinda D Wilkerson	11	Daughter
Jackson C Wilkerson	  6	Son
Luther M Wilkerson	  2	Son
John R Hathcock        	26	Brother in Law
Lee Lowe                   	25	Nephew